Ginger Extract May Prevent Prostate Cancer
Ginger has long been used as a traditional medicine to treat various conditions and symptoms, including vomiting, arthritis pain, and common cold, and a recent study found that ginger extract may slow the growth of prostate cancer.
According to a study conducted by researchers in Georgia State University and published in the British Journal of Nutrition, a whole ginger extract had significant effects in inhibiting the growth of cancer cells, as well as in inducing cell death in a spectrum of prostate cancer cells.
Despite a few studies have been done on the anti-cancer effects of ginger, the present study is the first report to describe identification and detailed evaluation of in vitro and in vivo anticancer activity of whole ginger extract in the therapeutic management of human prostate cancer.
The researchers prepared a ginger extract from whole ginger purchased at a local farmers market.
The extract was fed to mice at a dose of 100 mg/kg of body weight and was found to inhibit the progression of prostate cancer on mice by 56 percent.
Further analysis showed that the ginger extract inhibited the proliferation of the prostate cancer cells and increased apoptosis or programmed cell death, compared with control experiments.
Studies with human cells also revealed that ginger could perturb various cell functions that prevented the spread of the tumor. The researchers stress that no toxicity in normal tissues such as bone marrow and gut was observed.
Although further research is urgently needed, this study suggests that ginger extract has anti-cancer effects against human prostate cancer cells. No dosage for this purpose has been determined, but the study team performed allometric scaling calculations to extrapolate the mice dosage to humans.
The human equivalent dose of ginger extract was found to be approximately 567 mg daily for a 70 kg human adult. This may be viewed as an adjuvant therapy dosage, and an appropriate preventive dosage would be significantly less.